Highlight Photo
Cell targeting
Cell Targeting
Schematic depiction of proposed delivery strategy for multivalent targeting constructs in the brain to target tumor cells relative to non-tumor cells. (Left) Initially, the position of secondary tumors is not known and a catheter is placed in a region believed to contain secondary tumors. (Middle) Labeled constructs are injected through the catheter via convection-enhanced delivery; however, little contrast is observed between tumor sites and normal tissue. (Right) Artificial CSF is injected, unbound labeled construct is pushed away from the injection site by convection, and remaining bound constructs yield obvious contrast between tumor and non-target tissues.
Credits: Jill Stukel
