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Cell Patch and Membrane Sandwich Electroporation

Projects:
Molecular Engineering of Microdevices (MEMD)
Institution:
Ohio State University Research Foundation
Primary Strategic Goal:
Discovery: Foster research that will advance the frontiers of knowledge, emphasizing areas of greatest opportunity and potential benefit and establishing the Nation as a global leader in fundamental transformational science and engineering.
Secondary Strategic Goal:
Learning: Build the Nation's research capability through critical investments in advanced instrumentation, facilities, cyber infrastructure, and experimental tools.

Achievement/Results

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A nanofluidic “cell patch” device, which integrates layers of polymeric nanochannels into a single microfluidic device, has been developed in the laboratory of IGERT faculty L. James Lee and IGERT trainee Brian Henslee. When an electric field is applied, the nanochannels provide a focused electric field that can accelerate the transport of DNA or drugs into the cells close to the outlet of the nanochannels.


Provide a focused electric field that can accelerate the transport.

Address Goals

Current drug and gene delivery methods have limitations such as safety issues and low efficiency. This affordable “cell patch” device has great potential to deliver genes or drugs efficiently and safely at cell or tissue levels.

Posted:
February 16, 2009