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Novel Silica Nanoparticles Enhance Gene Delivery to the Spinal Cord: Potential to Control Pathological Pain
Behavioral responses to light mechanical touch stimuli applied to the hindpaws remains near baseline levels following intrathecal injection of protocells.
Graphs represent animal withdrawal responses from left (A, C) and right (B, D) hind paw responses following treatment with protocells supporting a DOTAP: CHOL 1:1 (A, B) or DOPC (C, D) lipid bilayer. The Y-axis (right) is the stimulus intensity in grams and the Y-axis (left) is the log stimulus intensity (mg x 10). The X- axis depicts time at baseline (BL) before injection and hours post injection of protocells (1mg).
Credits: Ellen Dengler, University of New Mexico
