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Increasing Efficacy for Lung Cancer Chemotherapeutics: Targeted Drug Delivery via the Protocell
Confocal Microscopy Positive EGFR-targeted Protocell Binding
Positive binding of EGF-conjugated protocell (no drug cargo in the protocell) on positive control, A549 cells displayed on both the left and right. The orthogonal view on the right shows a zoomed-in image of the EGF-conjugated protocell binding to the A549 plasma membrane. The stains seen in the confocal images are as follows: DAPI nuclear stain (contained in the VECTASHIELD HardSet Mounting Medium with DAPI), Invitrogen CellMask Orange plasma membrane stain (C10045), and Thermo Scientific Dylight 488 green in the MSNP cores of the protocell.
Credits: Annikka Jensen – University of New Mexico
