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Dynamic states of ErbB1 phosphorylation predicted by spatial-stochastic modeling
Receptor shuffle mechanism and state analysis
(A) Receptor shuffle mechanism. Two receptors dimerize, causing an asymmetric tail configuration leading to one tail being activated and phosphorylating the other tail. The dimer must then fall apart and re-dimerize in order to have both tails phosphorylated. (B) Receptor state transitions over a 4 minute simulation for a single ligand bound receptor (Top) and the average state through out a 4 minute simulation, of all ligand bound receptors (Bottom). © Receptor state transitions over a 4 minute simulation for a single unliganded receptor (Top) and the average state through out a 4 minute simulation, of unliganded receptors (Bottom).
Credits: Meghan M. McCabe, University of New Mexico
