Achievement

IGERT investigators are using developing sensors using bioluminescent proteins for diagnosis and monitoring of clinically relevant samples. Bioluminescent proteins provide many of the desired characteristics for such labels, including detection at extremely low concentrations, no interference from physiological fluids leading to excellent detection limits, and compatibility with many of the miniaturized systems such as lab-on-a-chip and lab-on-a-CD designs. However, the use of BL proteins has been restricted by the limited multiplexing capabilities. IGERT investigators have demonstrated that by combining both time and wavelength resolution the multiplexing capabilities of the photoprotein aequorin can be expanded. This research has resulted in a collaborative publication between Chemical Engineering and Chemistry.